Xin-Yuan Guan Selected Research

Peptide Initiation Factors (Initiation Factor)

1/2018	Eukaryotic Initiation Factor 5A2 Contributes to the Maintenance of CD133(+) Hepatocellular Carcinoma Cells via the c-Myc/microRNA-29b Axis.
1/2017	Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells.
8/2014	Ablation of EIF5A2 induces tumor vasculature remodeling and improves tumor response to chemotherapy via regulation of matrix metalloproteinase 2 expression.
7/2011	Overexpression of eIF5A-2 is an adverse prognostic marker of survival in stage I non-small cell lung cancer patients.
4/2010	Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma.
6/2004	Oncogenic role of eIF-5A2 in the development of ovarian cancer.

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Xin-Yuan Guan Research Topics

Disease

173	Neoplasms (Cancer) 04/2024 - 04/2002
65	Hepatocellular Carcinoma (Hepatoma) 03/2024 - 08/2002
61	Neoplasm Metastasis (Metastasis) 10/2023 - 12/2003
28	Carcinogenesis 11/2023 - 12/2003
27	Esophageal Squamous Cell Carcinoma 10/2023 - 09/2009
19	Carcinoma (Carcinomatosis) 04/2022 - 12/2003
17	Nasopharyngeal Carcinoma 07/2023 - 04/2003
11	Liver Neoplasms (Liver Cancer) 01/2023 - 02/2008
10	Lymphatic Metastasis 09/2022 - 12/2003
7	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 12/2003
6	Breast Neoplasms (Breast Cancer) 01/2022 - 07/2004
5	Stomach Neoplasms (Stomach Cancer) 04/2023 - 04/2009
5	Hypoxia (Hypoxemia) 01/2023 - 06/2014
5	Melanoma (Melanoma, Malignant) 01/2022 - 02/2004
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022 - 04/2014
5	Lung Neoplasms (Lung Cancer) 01/2022 - 04/2006
5	Esophageal Neoplasms (Esophageal Cancer) 01/2021 - 03/2016
5	Ovarian Neoplasms (Ovarian Cancer) 08/2013 - 06/2004
5	Chromosome Aberrations (Chromosome Abnormalities) 01/2012 - 04/2005
4	Chromosomal Instability (Chromosome Stability) 01/2018 - 07/2005
4	Infections 04/2016 - 08/2002
4	Cystadenoma 06/2010 - 01/2005
3	Squamous Cell Carcinoma of Head and Neck 11/2022 - 09/2007
3	Testicular Neoplasms (Testicular Cancer) 06/2022 - 05/2008
3	Residual Neoplasm 01/2021 - 07/2014
3	Genomic Instability 01/2017 - 08/2005
3	Adenoma (Adenomas) 01/2008 - 12/2003
2	Glioma (Gliomas) 11/2022 - 05/2014
2	Liver Cirrhosis (Hepatic Cirrhosis) 01/2020 - 06/2010

Drug/Important Bio-Agent (IBA)

44	Proteins (Proteins, Gene)FDA Link 03/2024 - 04/2003
23	Biomarkers (Surrogate Marker)IBA 01/2024 - 02/2008
20	RNA (Ribonucleic Acid)IBA 03/2024 - 05/2009
19	AgarIBA 11/2019 - 06/2004
14	MicroRNAs (MicroRNA)IBA 01/2020 - 12/2010
11	Cisplatin (Platino)FDA LinkGeneric 11/2023 - 04/2003
11	Sorafenib (BAY 43-9006)FDA Link 01/2023 - 05/2016
10	DNA (Deoxyribonucleic Acid)IBA 11/2018 - 04/2002
8	CateninsIBA 01/2019 - 01/2011
8	Messenger RNA (mRNA)IBA 01/2019 - 08/2007
7	Indicators and Reagents (Reagents)IBA 01/2024 - 08/2005
7	Transcription Factors (Transcription Factor)IBA 12/2022 - 01/2013
6	IntegrinsIBA 10/2023 - 11/2012
6	Cyclin D1IBA 12/2022 - 12/2009
6	Phosphotransferases (Kinase)IBA 01/2022 - 12/2009
6	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2019 - 07/2009
6	Adenosine Triphosphatases (ATPase)IBA 01/2019 - 07/2009
6	Peptide Initiation Factors (Initiation Factor)IBA 01/2018 - 06/2004
6	eIF-5A2IBA 05/2011 - 06/2004
5	Histones (Histone)IBA 04/2024 - 04/2006
5	Immune Checkpoint InhibitorsIBA 03/2024 - 01/2021
5	Neutralizing AntibodiesIBA 11/2023 - 03/2012
5	Conditioned Culture MediaIBA 11/2023 - 06/2009
5	Long Noncoding RNAIBA 09/2022 - 01/2019
5	AntigensIBA 06/2022 - 01/2021
4	NF-kappa B (NF-kB)IBA 04/2023 - 02/2004
4	CytokinesIBA 01/2022 - 01/2012
4	Carrier Proteins (Binding Protein)IBA 10/2021 - 08/2012
4	Matrix Metalloproteinases (MMPs)IBA 03/2021 - 04/2013
4	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 02/2016
4	EnzymesIBA 01/2020 - 02/2012
4	ClusterinIBA 06/2010 - 01/2005
3	Adenosine (Adenocard)FDA LinkGeneric 01/2023 - 02/2014
3	Neurofibromin 2 (Merlin)IBA 01/2023 - 01/2019
3	CollagenIBA 11/2022 - 08/2014
3	DNA HelicasesIBA 10/2021 - 09/2012
3	Small Interfering RNA (siRNA)IBA 11/2019 - 02/2014
3	hepatitis B virus X proteinIBA 01/2019 - 02/2004
3	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 11/2017 - 04/2013
3	immune RNA (I-RNA)IBA 01/2017 - 08/2013
3	Cadherins (E-Cadherin)IBA 11/2014 - 04/2007
3	Complementary DNA (cDNA)IBA 01/2013 - 05/2008
3	Calcibiotic Root Canal SealerIBA 07/2005 - 12/2003
2	Inosine FDA Link 01/2023 - 02/2014
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2023 - 02/2013
2	Adenosine DeaminaseIBA 01/2023 - 02/2013
2	LipidsIBA 01/2023 - 01/2012
2	rho GTPase-activating proteinIBA 01/2023 - 01/2020
2	AntioxidantsIBA 01/2023 - 01/2018
2	Fluorouracil (Carac)FDA LinkGeneric 11/2022 - 11/2022
2	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 04/2022 - 06/2009
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 06/2014
2	HMGB1 Protein (HMG1)IBA 01/2022 - 08/2009
2	LigandsIBA 01/2022 - 01/2020
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2021 - 10/2018
2	CalciumIBA 01/2021 - 11/2013
2	prenylIBA 12/2020 - 02/2009
2	Diphosphates (Pyrophosphates)IBA 12/2020 - 02/2009
2	Differentiation AntigensIBA 07/2020 - 08/2019
2	ChemokinesIBA 01/2020 - 01/2020
2	Amino Acids FDA Link 01/2020 - 04/2003
2	Cell Adhesion MoleculesIBA 01/2019 - 04/2007
2	Protein Isoforms (Isoforms)IBA 10/2018 - 08/2010
2	Insulin-Like PeptidesIBA 01/2018 - 01/2012
2	16-iodo-3-methylhexadecanoic acid (MIHA)IBA 01/2018 - 08/2008

Therapy/Procedure

34	Therapeutics 11/2023 - 07/2004
17	Drug Therapy (Chemotherapy) 11/2023 - 04/2003
9	Immunotherapy 01/2024 - 01/2020
6	Radiotherapy 07/2023 - 09/2007
5	Chemoradiotherapy 01/2020 - 09/2009
3	Lasers (Laser) 01/2022 - 05/2009